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張素瓊 女士

經歷

  • 國立成功大學 特聘教授

  • 日本東京大學 客座教授

  • 美國德拉瓦大學 客座學者

  • 國立成功大學生命科學系(所) 系主任、所長、生物多樣性研究所 所長

  • 國立成功大學生物科學與科技學院代理院長、熱帶植物科學研究所代理所長

  • 衛生福利部食品藥物管理署健康食品審議委員會諮議委員、審議委員

  • 經濟部保健食品專業人才能力鑑定 指導委員、保健食品研發工程師 專門委員

  • 科技部計畫審查委員

  • 教育部科學教育指導委員會諮詢委員

  • 行政院國家科學委員會生命科學推動中心 審議委員

  • 台灣保健食品學會 理事長 、常務理事、理事

  • 台灣營養學誌、地質醫學 總編輯

  • 國際期刊論文審查

  • 食品工業發展研究所學術倫理審議委員會委員

學歷與考試

  • 美國普渡大學(Purdue University)食品營養研究所 博士

  • 美國普渡大學(Purdue University)食品營養研究所 碩士

著作-【專書】

  • 張素瓊* 2018. 香椿與基因調控-以PDXK基因為例 In:蒼生之椿. 香椿研究團隊及同好. P.109 ISBN:978-957-43-2811-6
  • 張素瓊*、游步青、陳盈心. 2018. 香椿與蛋白質體學-以睪丸組織為例. In:蒼生之椿. 香椿研究團隊及同好. P.119 ISBN:978-957-43-2811-6
  • 張素瓊* 2018. 踏上香椿研究之路-香椿與男性不孕. In: In:蒼生之椿. 香椿研究團隊及同好. P.131 ISBN:978-957-43-2811-6
  • 張素瓊*、尤文正、郭棠峰. 2018. 體內抗氧化防禦系統-抗氧化與解毒酵素. In:香椿之奧妙. 香椿研究團隊及同好. P.89,ISBN:978-957-43-2810-9
  • 張素瓊*、張雲晶、劉宏文. 2018.香椿改善胰島素抗性的分子醫學證據. In:香椿之奧妙.香椿研究團隊及同好. P.169, ISBN:978-957-43-2810-9
  • 張素瓊*. 2007. 2012. 香椿與男性不孕. In:繼往開來-台灣之椿. 台灣香椿研究團隊合著. P. 33-35.初版. ISBN: 978-986-83607-0-9. P. 129-39.增訂版. ISBN: 978-986-83607-0-9
  • 張素瓊*、許方. 2007. 2012. 香椿與基因調控. In:繼往開來-台灣之椿. 台灣香椿研究團隊合著. P. 80-82. 初版.ISBN: 978-986-83607-0-9. P. 221-6. 增訂版.ISBN: 978-986-83607-0-9
  • 張素瓊*、陳盈心. 2007. 2012. 香椿與蛋白質體學. In:繼往開來-台灣之椿. 台灣香椿研究團隊合著. P. 83-85. 初版.ISBN: 978-986-83607-0-9. P. 227-32. 增訂版.ISBN: 978-986-83607-0-9
  • 張素瓊*、郭棠峰. 2007. 2012. 體內抗氧化防禦系統. In:繼往開來-台灣之椿. 台灣香椿研究團隊合著. P. 103-105. 初版.ISBN: 978-986-83607-0-9. P. 139-142. 增訂版. ISBN: 978-986-83607-0-9
  • 魏燕蘭, 張素瓊, 黃怡嘉. 2003.  維生素B6.  In:國人膳食營養素參考攝取量及其說明 (修訂第六版). 行政院衛生署. P.164-188
  • 張素瓊 .2003.  維生素B6.  In:每日營養素建議攝取量及其說明 (修訂第五版). 行政院衛生署. P.56-71
  • 張素瓊*. 2003.  7-12歲年齡層維生素B6需要量之研究. DOH89-TD-1055. P.1-70.
  • Chang S.-J., Huang, C-Y and Chan Y-C. Diorcorea opposite (Shan Yao,山藥) In:Dietary Chinese Herbs:Chemistry, Pharmacology, and Clinical Evidences. Springer, 2015. P.113-125. ISBN: 978-3-211-99447-4.
  • Chang S.-J., Chan,Y-C, and Yu, W-J. Glycyrrhiza uralensis (Gan-Cao, 甘草) In:Dietary Chinese Herbs:Chemistry, Pharmacology, and Clinical Evidences. Springer, 2015. P.135-145. ISBN: 978-3-211-99447-4.
  • Chang S.-J. and Huang C.-Y. Proteomics analysis of the functionality of Toona sinensis by 2D-gel electrophoresis. In: Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods. Wiley-Blackwell, April, 2010 ISBN: 978-0-8138-1402-5
  • Chang S.-J. and Chow, C.-K. Intake/consumption of fatty acids. In: Fatty Acids in Foods and Their Health Implications, 3rd Edition, Revised and Expand. (Edited by Ching Kuang Chow) CRC Press. USA. October, 2007. ISBN: 978-084-93726-1-2
  •  Chang S.-J. and Chow, C.-K. Fatty acids in fermented food products. In: Fatty Acids in Foods and Their Health Implications, 3rd Edition, Revised and Expand. (Edited by Ching Kuang Chow) CRC Press. USA. October, 2007. ISBN: 978-084-93726-1-2

期刊或研討會論文

  • Yun-Ching Chang, Yin-Chin Chan, Shu-Hui Hu, Ming-Yi Liu, Sue-Joan Chang*. The green tea polyphenol epigallocatechin-3-gallate attenuates age-associated muscle loss via regulation of myostatin and miR-486.Archives of Biochemistry and Biophysics.2020 (撰寫中4月底截稿,IF: 3.559) (SCI)

  • Shui-Yuan Feng, Lean-Teik Ngc, Jhih-Yi Liu, Shu-Jing Wu,* and Sue-Joan Chang*. Anthocyanin-rich black rice ethanol extracts exhibit anti-obesity effects via activating Sirt1/ PGC-1α/PPAR-γ mediated fatty acid oxidation and HSL- mediated lipolysis and inhibiting FAS-mediated lipogenesis in 3T3-L1 adipocytes. Journal of Cereal Science.2020 (投稿中) (SCI)

  • Hung-Wen Liu, Yun-Ching Chang, Yin-Ching Chan, Shu-Hui Hu, Ming-Yi Liu, Sue-Joan Chang*. Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice. Biogerontology. 2020 May 21(3), 367-380 (SCI) ( IF: 3.77)

  • Chan YC, Wu CS, Wu TC, Lin YH, Chang SJ*. A Standardized Extract of Asparagus officinalis Stem (ETAS®) Ameliorates Cognitive Impairment, Inhibits Amyloid β Deposition via BACE-1 and Normalizes Circadian Rhythm Signaling via MT1 and MT2. Nutrients. 2019 Jul 17;11(7). pii: E1631. (SCI) (IF:4.171)

  • Chang YC, Chen YT, Liu HW, Chan YC, Liu MY, Hu SH, Tseng WT, Wu HL, Wang MF, and Chang SJ. Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality. Mol Nutr Food Res.2019 May; 63(10):e1801101.(SCI) (IF:4.909)

  • Chen YF, Chang CH, Huang ZN, Su YC, Chang SJ, Jan JS. The JAK inhibitor antcin H exhibits direct anticancer activity while enhancing chemotherapy against LMP1-expressed lymphoma. Leuk Lymphoma.2019 May; 60(5). (SCI) (IF:3.093)

  • Chang YC, Liu HW, Chen YT, Chen YA, Chen YJ and Chang SJ*. Resveratrol protects muscle cells against palmitate-induced cellular senescence and insulin resistance through ameliorating autophagic flux. J Food Drug Anal. 2018 Jul;26(3):1066-1074. (SCI)

  • Liu HW and Chang SJ. Moderate Exercise Suppresses NF-κB Signaling and Activates the SIRT1-AMPK-PGC1α Axis to Attenuate Muscle Loss in Diabetic db/db Mice. Front Physiol. 2018 May 29;9:636. (SCI)

  • Liu HW, Chen YJ, Chang YC and Chang SJ*. Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1. Nutrients. 2017 Sep 20;9(9). pii: E1040. (SCI) 

  • Liu HW, Chan YC, Wei CC, Chen YA, Wang MF and Chang SJ*. An alternative model for studying age-associated metabolic complications: Senescence-accelerated mouse prone 8. Exp Gerontol. 2017 Aug 23. 99:61-68. (SCI)

  • Hu SH, Chen KS, Liu MY, Cheung CK, Wang JC, Chang SJ*. Optimization of Submerged Cultivation Conditions for Production of Big Cup Culinary-Medicinal Mushroom Clitocybe maxima (Agaricomycetes) Biomass with Significant Antioxidative and Antihyperlipidemic activities. Int J Med Mushrooms. 2017;19(7) (SCI) 

  • Chen YF, Shiau AL, Chang SJ, Fan NS, Wang CT, Wu CL, Jan JS. One-dimensional poly(L-lysine)-block-poly(L-threonine) assemblies exhibit potent anticancer activity by enhancing membranolysis. Acta Biomater. 2017 Jun;55:283-295. (SCI)

  • Liu MY, Tang HC, Hu SH, Chang SJ* Peptide-based enteral formula improves tolerance and clinical outcomes in abdominal surgery patients relative to a whole protein enteral formula. World J Gastrointest Surg. 2016 Oct 27;8(10):700-705. 

  • Liu HW, Wei CC, Chen YJ, Chen YA, Chang SJ* Flavanol-rich lychee fruit extract alleviates diet-induced insulin resistance via suppressing mTOR/SREBP-1 mediated lipogenesis in liver and restoring insulin signaling in skeletal muscle. Mol Nutr Food Res. 2016,60:2288-2296 (SCI) 

  • Liu HW, Wei CC, Chang SJ* Low-molecular-weight Polyphenols Protect Kidney Damage through Suppressing NF-B and Modulating Mitochondrial Biogenesis in Diabetic db/db Mice. Food & Function. 2016; 7. 1941-9. (SCI) 

  • Liu HW, Chan YC, Wang MF, Wei CC, Chang SJ*. Dietary (-)-epigallocatechin-3-gallate supplementation counteracts aging-associated skeletal muscle insulin resistance and fatty liver in senescence-accelerated mouse. J Agric Food Chem. 2015 Sep 30;63(38):8407-17. doi: 10.1021/acs.jafc.5b02501. Epub 2015 Sep 15.(SCI)

  • Liu H. W., Wei C. C., Chen Y.J., Chen Y.A., and Chang S.J. 2016.Flavanol-rich lychee fruit extract alleviates diet-induced insulin resistance via suppressing mTOR/SREBP-1 mediated lipogenesis in liver and restoring insulin signaling in skeletal muscle. MolNutr Food Chem.Accepted manuscript online: DOI: 10.1002/mnfr.201501064

  • Liu H. W., Wei C. C., and Chang S.J. 2016. Low-molecular-weight Polyphenols Protect Kidney Damage through Suppressing NF-κB and Modulating Mitochondrial Biogenesis in Diabetic db/db Mice. Food & Function.7:1941-9.

  • Liu H.W., Huang W.C., Yu W.J., and Chang S.J. 2015, DOI: 10.1039/C5FO00056D. Toona Sinensis ameliorates insulin resistance via AMPK and PPARγ pathways. Food & Function. SCI Journal in FOOD SCIENCE & TECHNOLOGY Impact factor: 2.907;Ranking: 16/123 (13%)

  • Liu MY, Chen YY, Hu SH, Chen YK, Chang SJ. (2015). The Influence of Aggressive Parenteral Nutrition to Preterm and Very Low Birth Weight Infants. Global Pediatric Health, 2, 2333794X14567192.  

  • Liu MY, Tang HC, Hu SH, Yang HL, Chang SJ. (2015). Influence of Preoperative Peripheral Parenteral Nutrition with Micronutrients after Colorectal Cancer Patients. BioMed Research International, Article ID 535431, 6 pages,(SCI)

  • Liu MY, Tang HC, Yang HL, Chang SJ. (2014). A Short Bowel (Small Intestine= 40 cm), No Ileocecal Valve, and Colonic Inertia Patient Works Well with Oral Intake Alone without Parenteral Nutrition. Case reports in surgery, Article ID 387307, 3 pages. (SCI)

  • Liu, Hung-Wen; Tsai, Yue-Tseng; Chang, Sue-Joan* Toona sinensis leaf extract inhibits lipid accumulation through up-regulation of genes involved in lipolysis and fatty acid oxidation in adipocytes. J Agric. Food Chem. 2014 Jun 25;62(25):5887-96. doi: 10.1021/jf500714c. Epub 2014 Jun 11. (SCI)

  • Ming-Yi Liu, Hsiu-Chih Tang, Hui-Lan Yang and Sue-Joan Chang* A short bowel (small intestine = 40cm), no ileocecal valve and colonic inertia patient works well with oral intake alone without parenteral nutrition. Case Rep Surg. 2014; 2014:387307.doi: 10.1155/2014/387307. Epub 2014 Jun 15. (SCI)

  • Chen YF, Shiau AL, Wang SH, Yang JS, Chang S.-J., Wu CL, Wu TS. Zhankuic acid A isolated from Taiwanofungus camphoratus is a novel selective TLR4/MD-2 antagonist with anti-inflammatory properties. J Immunol. 2014 Mar 15; 192(6):2778-86. doi: 10.4049/jimmunol.1301931. Epub 2014 Feb 14. (SCI)

  • Liu MY, Tang HC, Yang HL, Huang HH, Chang S.-J.* Hypo-calories with micronutrients and fat emulsion of pre-operative peripheral parenteral nutrition in malnutrition risk rectal cancer patients: A retrospective cross-sectional study. Food and Nutrition Sciences. 2013 Aug 4(8):821. DOI: 10.4236 (SCI)

  • Jinnchyi Wang, Chihchung Wu, Yukuei Chen, Chenyu Chen, Shuhui Hu, Suejoan Chang*.  Antihyperglycemic Activity of Exopolysaccharide Produced by Mushroom Pleurotus ferulae with Submerged Liquid Culture on Streptozotocin-induced Diabetic Rats. Journal of Food and Nutrition Research, 2014, Vol. 2, No. 7, 419-424. DOI:10.12691/jfnr-2-7-15 (SCI) 

  • Chang S.-J.*, Huang HH, Diarrhea in enterally fed patient: blame the diet? Curr Opin Clin Nutr Metab Care.  2013 Sep; 16(5):588-94. doi: 10.1097/MCO.0b013e328363bcaf. [Epub ahead of print] (SCI)

  • Hsu YC, Chang S.-J., Wang MY, Chen YL, Huang TY.Growth inhibition and apoptosis of neuroblastoma cells through ROS-independent MEK/ERK activation by sulforaphane. Cell Biochem Biophys. 2013 Jul; 66(3):765-74. doi: 10.1007/s12013-013-9522-y. (SCI)

  • Hu SH, Wu CY, Chen YK, Wang JC, Chang S.-J.* Effect of light and atmosphere on the cultivation of Pleurotus citrinopileatus. Int. J. Med. Mushrooms, 2013; 15: 101-11. (SCI)

  • Yu BC, Yu WJ, Huang CY, Chen YH, Tsai YC, Chang CC, Chang S.-J.* Toona sinensis leaf aqueous extract improves the functions of sperm and testes via regulating testicular proteins in rats under oxidative stress. Evid Based Complement Alternat Med. 2012:681328 (SCI)

  • Huang HH, Chang S.-J.*, Hsu CW, Chang TM, Kang SP, Liu MY. Severity of Illness Influences the Efficacy of Enteral Feeding Route on Clinical Outcomes in Patients with Critical Illness. J Acad Nutr Diet. 2012,112(8)1138-46 (SCI)

  • Yu WJ, Yu BC, Yang FY, Chang CC, Huang CY, Chang S.-J.*, Toona Sinensis Affects Reproductive Physiology of Male .J Food Drug Anal. 20( Suppl. 1).2012; 332-6 (SCI)

  • Yu WJ, Chang CC, Kuo TF, Tsai TC, Chang S.-J.*.Toona sinensis Roem leaf extracts improve antioxidant activity in the liver of rats under oxidative stress. Food Chem Toxicol.2012; 50:1860-5(SCI)

  • Otani L, Ogawa S, Zhao Z, Nakazawa K, Umehara S, Yoshimura E, Chang S.-J., Kato H. Optimized method for determining free L-cysteine in rat plasma by high-performance liquid chromatography with the 4-aminosulfonyl-7-fluoro-2,1,3-benzoxadiazole conversion reagent. Biosci Biotechnol Biochem.2011; 75:2119-24. (SCI)

  • Otani L, Sugimoto N, Kaji M, Murai M, Chang S.-J., Kato H, Murakami T. Role of the renin-angiotensin-aldosterone system in the enhancement of salt sensitivity caused by prenatal protein restriction in stroke-prone spontaneously hypertensive rats. J Nutr Biochem.2011; 23:892-9 (SCI)

  • Chang S.-J.*, Yu BC. Mitochondrial matters of the brain: mitochondrial dysfunction and oxidative status in epilepsy. J Bioenerg Biomembr. 2010; 42:457-9. (SCI)

  • Wu MH, Pan TM, Wu YJ, Chang S.-J., Chang MS, Hu CY. Exopolysaccharide activities from probiotic bifidobacterium: Immunomodulatory effects (on J774A.1 macrophages) and antimicrobial properties. Int J Food Microbiol. 2010; 144:104-10. (SCI)

  • Tsai HL, Chang CN, Chang S.-J.*. The effects of pilocarpine-induced status epilepticus on oxidative stress/damage in developing animals. Brain Dev.2010; 32:25-31 (SCI)

  • Tsai HL, Yan JL,Wang SM, Chang S.-J.*, Neuroprotection Against Hyperhomocysteinemia-Induced Selective Oxidative Stress in Brain Regions of Rats with Folic Acid or Dioscorea Alata Supplementation. Current Topics in Nutraceutical Research. 2009; 7,2, (SCI) 

  • Hu SH, Liang ZC, Lie JL, Hsieh SL, Wang JC, Chang S.-J.*, Antioxidant and Antigenotoxicity Activities of Extracts from Liquid Submerged Culture of Culinary–Medicinal Ferula Oyster Mushroom, Pleurotus eryngii (DC.) Qu, I. Int. J. Med. Mushrooms.2009; 11:395- 408. (SCI)

  • Hu, S-H, Wang, J-C, Wu, C-Y, Hsieh, S-L, Chen, K-S, Chang, S.-J., Liang, Z-C*. Bioconversion of Agro Wastes for the Cultivation of the Culinary-Medicinal Lion’s Mane Mushroo,s Hqericium erinaceus(Bull.:Fr.)Pers. And H. lacimiatum (Leers) Banker (Aphyllophoromycetideae) in Taiwan. Int. J. Med. Mushrooms.2008; 10:385-398. (SCI) 

  • Tsai, H-L, Chang, Sam K-C, Lin, Y-F and Chang, S.-J.*.  Beneficial Effects of Maternal Vitamin E Supplementation on the Antioxidant System of the Neonate Chick Brain. Asian-aust. J. Anim. Sci.2008; 21:225-31. (SCI) 

  • Chow. C-K* and Chang, S.-J.. Value or Usefulness of Food Frequency Questionnaire for the Assessment of Dietary Total Antioxidant Capacity. J Nutr.. 2007; 137: 1496-7. (SCI) 

  • Tsai, H-L, Chang, Sam K-C, Chang, S.-J.*. Antioxidant Content and Free Radical Scavenging Ability of Fresh Red Pummelo (Citrus grandis (L.) Osbeck) Juice and Freeze-dried Products. J. Agri. Food. Chem.2007; 55:2867-72. (SCI) 

  • Chang, S.-J.*, Hsiao, L-J, Lee, Y-C, and Hsuen, S-Y. Vitamin B6 Status Assessment in Relation to Dietary Intake in High School Students Aged 16-18 Years. Bri. J. Nutr. 2007; 97: 764-9. (SCI) 

  • Chang, S.-J.*.  Function and Development of Chinese Yam (Dioscorea). Taiwan Food News. 2006; 212:44-47. 

  • Tsai, H-L and Chang, S-J*.  The Mini Nutritional Assessment (MNA) is Used in Screening Nutritional Status of Elders in Nursing Home. Nutr. Sci. J.2006; 30: 135-45.  

  • Lin, Y-F, Chang, S-J*.. Effect of Dietary Vitamin E on Growth Performance and Immune Response of Breeder Chickens. Asian-Australia. J. Anim. Sci.2006; 19: 884-91. (SCI) 

  • Su, T-C, Jeng, J-S, Wang, J-D, Torng, P-L, Chang, S.-J., Chen, C-F and Liau, C-S*.   Homocysteine, Circulating Vascular Cell Adhesion Molecule and Carotid Atherosclerosis in Postmenopausal Vegetarian Women and Omnivores.  Atherosclerosis. 2006; 184:356-62. (SCI)  

  • Lin, Y-F, Tsai, H-L, Lee, Y-C and Chang, S.-J.*.Maternal Vitamin E Supplementation Affects the Antioxidant Capability and Oxidative Status of Hatching Chicks. J. Nutr.2005; 135: 2457-61. (SCI) 

  • Lin, Y-F, Chang, S.-J.*, Yang, J-R, Lee, Y-P and Hsu, A-L. Effects of Supplemental Vitamin E during the Mature Period on the Reproduction Performance of Taiwan Native Chickens Cockerels. Brit Poultry Sci.2005; 46:366-73. (SCI) 

  • Lin, Y-F, Chang, S.-J.* and Hsu, A-L. Effects of Supplemental Vitamin E during the Laying Period on Reproductive Performance of Taiwan Native Chickens. Brit. Poultry Sci.2004; 45:807-14. (SCI) 

  • Chang, S.-J.*, Lee, Y-C, Liu, S-Y. and Chang, T-W. Chinese Yam (Dioscorea alata cv. Tainung NO.2) Feeding Exhibits Antioxidative Effects in Hyperhomocysteinemia Rats. J. Agri. Food Chem.2004; 52:1720-25 (SCI)

專長

  • 保健食品

  • 營養學、營養基因體學

  • 蛋白質體學

  • 人體生理學

  • 細胞生物學

榮譽

  • 國立成功大學「特聘教授」、免評量教授

  • 台灣保健食品學會「傑出學術研究暨技術開發獎」

  • 中華民國營養學會「營養學術研究傑出獎」

  • 輔仁大學「傑出校友獎」

  • 日本學術振興會海外研究員

  • 國科會100年獎勵特殊優秀人才

  • MARQUIS Who’s Who in the World 2012, 2015 (29th, 32th Editions)

  • Gamma Sigma Delta, The Honor Society of Agriculture, 傑出成就

  • 普渡大學榮譽終身校友